The Role of Exercise in Adaptation and Body Response to Doxorubicin-Induced Cellular Toxicity: A Narrative Review Study

Doxorubicin is an anthracycline antibiotic used for the treatment of a wide range of cancers. But unfortunately, due to its accumulation within healthy tissues, DOX treatment results in side effects of cellular toxicity. DOX-induced cellular toxicity occurs as a result of increasing oxidative damage, resulting in apoptosis and cell death. There is currently no standard of care practice to prevent DOX-induced toxicity to off-target organs. Therefore, scientists and researchers are seeking to further development and improvement of the treatment for this deadly disease. Meanwhile, the combination of exercise and chemotherapy is a promising method for efficiency and tolerance and reduction of side effects and drug resistance. Physical activities stimulate numerous beneficial biochemical adaptations resulting in a healthy phenotype in vulnerable tissues, without affecting the antineoplastic properties of DOX. Therefore, determining the appropriate exercise regimen is important to prescribe those cancer patients receiving DOX therapy because the patientchr('39')s physical and medical conditions must be considered. The present review study investigates the cytotoxic effects of DOX on the heart, liver, kidney and lungs, discussing the benefits of the role of regular physical activity and potential mechanisms dealing with the positive effects of exercise on each system. Key words: Cancer, Doxorubicin, Cytotoxicity, Exercise   Funding: This study did not have any funds. Conflict of interest: None declared Ethical approval: None declared   How to cite this article: Hashemi Chashemi S Z, Hojati S S, Dabidiroshan V, Jalali Dehkordi Kh. The Role of Exercise in Adaptation and Body Response to Doxorubicin-Induced Cellular Toxicity: A Narrative Review Study. J Rafsanjan Univ Med Sci 2020; 19 (8): 869-88. [Farsi]